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Paragon Bioservices Selected by IAVI for Manufacture of HIV Vaccine Candidate
December 4, 2015
Paragon Bioservices, a global leader in the manufacturing of biopharmaceuticals and vaccines, has been awarded a contract by the International AIDS Vaccine Initiative (IAVI) for the process development, analytical development and cGMP manufacturing of a promising HIV vaccine candidate that will undergo animal and, subsequently, clinical testing.
In findings reported in June, researchers showed that an experimental vaccine candidate could stimulate the immune system to produce antibodies that, if further matured, could potentially block HIV infection in mice. The candidate's "eOD-GT8 60mer" immunogen is a protein nanoparticle designed to mimic a critical part of the HIV envelope protein and to bind and activate B cells to produce antibodies capable of fighting HIV. The researchers showed that immunization of mice with eOD-GT8 60mer produced antibody "precursors" with some of the traits necessary to recognize and block HIV infection, suggesting that the eOD-GT8 60mer could be a good first step in a series of immunizations against HIV.
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